醫學界視苯二氮䓬類藥物較以往常用的巴比妥鹽類藥物更好，因為後者的治療劑量和中毒劑量差距較少（即是稍微過量便容易中毒），且会形成较强的依赖性。過量服用地西泮較不容易引致死亡（不過仍然有人因服用地西泮過量而死亡），但如同時服用其它鎮靜劑或酒類則會增加危險。
Diazepam can continue to be detected prolonged after it has still left the process. Saliva, blood, and urine tests are the most typical and productive way to ascertain how much time the final dose was taken. Urine checks can detect diazepam for months after the last dose.
There's a probably applicable conversation between diazepam and compounds which inhibit specific hepatic enzymes (specially cytochrome P450 3A and 2C19).
In equally untimely and comprehensive expression infants the Energetic metabolite desmethyldiazepam shows evidence of continued accumulation when compared to small children. For a longer period 50 percent-lives in infants could possibly be on account of incomplete maturation of metabolic pathways.
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Reserve concomitant prescribing of such medication in patients for whom alternate cure alternatives are insufficient.
薬の処方ハンドブック（羊土社） — 類似の処方集に「今日の処方」（南江堂）などがある。
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Doses of diazepam are proposed for being about fifty percent of Those people given to younger persons, and therapy is restricted to a utmost of two months. Lengthy-acting benzodiazepines including diazepam aren't encouraged for that elderly.[20] Diazepam can be unsafe in geriatric patients owing to some drastically improved risk of falls.[62]
Just like other agents which have anticonvulsant activity, when diazepam is made use of as an adjunct in dealing with convulsive Issues, the possibility of an increase in the frequency and/or severity of grand mal seizures may perhaps demand a rise in here the dosage of standard anticonvulsant medication.
Metabolism: Diazepam is N-demethylated by CYP3A4 and 2C19 to your Lively metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 towards the active metabolite temazepam.
Diazepam, as with other benzodiazepine medicine, may cause tolerance, Actual physical dependence, compound use dysfunction, and benzodiazepine withdrawal syndrome. Withdrawal from diazepam or other benzodiazepines usually results in withdrawal signs and symptoms comparable to Individuals viewed in the course of barbiturate or Liquor withdrawal.